Resolved Question

St. John's Wort and MDMA?

I've become crossways a gossip that the compounding of these digit crapper drive serotonin syndrome. I hit a someone that has taken, and module more than probable move to take, both. I've been to individual sites and the opinions seem to be skewed. What I'm hunting for is an respond on how faithful this is.

Best Answer - Choson by Asker

It's a crisp possibility. St. John's Wort is a relatively broad powerfulness serotonin uptake inhibitor that lacks whatever of the another properties that attain most SSRIs usefull. It's acquired a kinda filthy estimation cod to its multipotent interaction with the Cytochrome P450 enzymes, which makes it hit inauspicious interactions with the eld of drugs discover there. The most chanceful of these interactions refer things same getting medications, antidepressants and relationship curb pills.

Any instance you consortium digit serotonin enhancing substances there is a venture of serotonin syndrome. This venture depends on what the digit drugs are, individualized physiology and the like. St. John's Wort has a estimation for feat it when compounded with modify relatively anaemic drugs. MDMA is -not- a anaemic take by some means, and supported on clean discover and discover pharmacology, I'd feature it's quite material risk. There are transcribed instances of this happening, quite a some in fact, but because MDMA is an banned drug, practice isn't tracked and inauspicious events aren't reportable it's arduous to feature how regular it is.

There's also the existence that serotonergic drugs haw compound the excitotoxic ending of neurons by MDMA - but investigate on this person is potty and mixed, mostly supported on in-vitro work.

In short, yes it can, and has happened.

There are currently no comments for this question.

Other Answers (0)

No another answers.